Hydrochloric Acid → 2-(4-(2-Hydroxyethyl)phenoxy)acetaldehyde

HRID 470958ノート

反応式

HRID 470958 の反応式
Cl.C([O:4][CH:5](OCC)[CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=1)C>O1CCOCC1.O>[OH:16][CH2:15][CH2:14][C:11]1[CH:12]=[CH:13][C:8]([O:7][CH2:6][CH:5]=[O:4])=[CH:9][CH:10]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 579889402-(4-(2,2-Diethoxyethoxy)phenyl)ethanol

生成物 1

HCID 545162782-(4-(2-Hydroxyethyl)phenoxy)acetaldehyde

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

Concentrated hydrochloric acid (5 mL) was added to a solution of 2-(4-(2,2-diethoxyethoxy)phenyl)ethanol (example 3, step a) (0.76 g) in 1,4-dioxane (10 mL) and the resulting mixture was stirred for 1 h. The reaction was diluted with water (50 mL) and extracted with ethyl acetate (3×50 mL). The combined organic solutions were washed with water (50 mL) and brine (50 mL), then dried over sodium sulphate, filtered and evaporated in vacuo to give the subtitled compound, which was used directly. Yield 0.35 g.

後処理

  1. extractionextracted with ethyl acetate (3×50 mL)
  2. washThe combined organic solutions were washed with water (50 mL) and brine (50 mL)
  3. dry with materialdried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-c1cc1aff49664670afc56c256dc7dcfb
出典データセット
uspto-grants-2014_01
特許番号
US08629271B2

反応ノート

読み込み中…