2-(3-(Hydroxymethyl)phenyl)ethanol → 3-(2-Hydroxyethyl)benzaldehyde

HRID 471009ノート

反応式

HRID 471009 の反応式
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][OH:11])[CH:6]=[CH:7][CH:8]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[OH:11][CH2:10][CH2:9][C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=1)[CH:2]=[O:1]

参加物

4

反応物 1

HCID 579891802-(3-(Hydroxymethyl)phenyl)ethanol

生成物 1

HCID 184247323-(2-Hydroxyethyl)benzaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

Manganese (IV) dioxide (2.0 g) was added to a stirred solution of 2-(3-(hydroxymethyl)phenyl)ethanol (example 20, step a) (0.50 g) in DCM (10 mL) at room temperature. After 6 h, the reaction mixture was filtered through Celite eluting with DCM. The solution was evaporated in vacuo to give the subtitled compound as a gum. Used directly. Yield 0.46 g.

後処理

  1. filtrationthe reaction mixture was filtered through Celite
  2. washeluting with DCM
  3. customThe solution was evaporated in vacuo

出典と根拠

ORDレコード
ord-efac4ab287c8441782cb6690e566ee72
出典データセット
uspto-grants-2014_01
特許番号
US08629271B2

反応ノート

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