Ammonium Chloride → 2-(3-(Diethoxymethyl)phenyl)ethanol

HRID 471010ノート

反応式

HRID 471010 の反応式
[Cl-].[NH4+].[OH:3][CH2:4][CH2:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)C=O.C(O[CH:17]([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20])C>CCO>[CH2:22]([O:21][CH:17]([O:18][CH2:19][CH3:20])[C:12]1[CH:13]=[C:6]([CH2:5][CH2:4][OH:3])[CH:7]=[CH:8][CH:11]=1)[CH3:23]

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 31214Ethyl orthoformateHCID 184247323-(2-Hydroxyethyl)benzaldehyde

生成物 1

HCID 579893032-(3-(Diethoxymethyl)phenyl)ethanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

Ammonium chloride (0.08 g) was added to a solution of 3-(2-hydroxyethyl)benzaldehyde (example 20, step b) (0.45 g) and triethoxymethane (0.55 g) in EtOH (8 mL) and the reaction mixture heated at 70° C. for 3 h. After cooling, the reaction mixture was partitioned between ethyl acetate and saturated sodium bicarbonate solution. The ethyl acetate solution was dried over sodium sulphate, filtered and evaporated in vacuo to give the subtitled compound as a gum. Yield 0.24 g.

後処理

  1. temperatureAfter cooling
  2. customthe reaction mixture was partitioned between ethyl acetate and saturated sodium bicarbonate solution
  3. dry with materialThe ethyl acetate solution was dried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-b816f858efe1483ab26803c83b8914fe
出典データセット
uspto-grants-2014_01
特許番号
US08629271B2

反応ノート

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