Imidazole → (2-(3-Bromophenyl)-2-fluoroethoxy)(tert-butyl)dimethylsilane

HRID 471057ノート

反応式

HRID 471057 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([F:11])[CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.N1C=CN=C1.[C:17]([Si:21]([CH3:24])([CH3:23])Cl)([CH3:20])([CH3:19])[CH3:18]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([F:11])[CH2:9][O:10][Si:21]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:24])[CH3:23])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 579893062-(3-Bromophenyl)-2-fluoroethanol

生成物 1

HCID 57989324(2-(3-Bromophenyl)-2-fluoroethoxy)(tert-butyl)dimethylsilane

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 2-(3-bromophenyl)-2-fluoroethanol (example 39, step b) (1.38 g) and imidazole (1.29 g) in DMF (14 mL) was cooled in ice-water, treated with tert-butyldimethylchlorosilane (1.049 g), then removed from the cooling bath and stirred at room temperature overnight. The solution was poured into water and extracted twice with diethyl ether. The combined organic extracts were washed twice with water, once with brine, then dried over anhydrous magnesium sulphate and purified by flash chromatography on silica eluted with 10% dichloromethane in isohexane to afford the subtitled compound as a colourless oil. Yield 1.94 g.

後処理

  1. customremoved from the cooling bath
  2. additionThe solution was poured into water
  3. extractionextracted twice with diethyl ether
  4. washThe combined organic extracts were washed twice with water, once with brine
  5. dry with materialdried over anhydrous magnesium sulphate
  6. custompurified by flash chromatography on silica
  7. washeluted with 10% dichloromethane in isohexane

出典と根拠

ORDレコード
ord-79736d1fc8f447d39a64373e8319cee3
出典データセット
uspto-grants-2014_01
特許番号
US08629271B2

反応ノート

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