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Sodium Bicarbonate → 4,4-Dimethyl-7-propionylamino-8-nitro-2H,4H-isoquinoline-1,3-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione | HCID 11833171 | — |
| 溶媒 | Propionic anhydride | HCID 31263 | — |
| 生成物 | 4,4-Dimethyl-7-propionylamino-8-nitro-2H,4H-isoquinoline-1,3-dione | HCID 20384930 | — |
反応手順
29.1 gm of 4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione were refluxed for 4 hours with 50 ml of propionic acid anhydride. The mixture was then poured into ice water and neutralized with sodium bicarbonate. The obtained precipitate was purified on a silicagel column (eluant: chloroform/acetone 19:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04176184 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-4924df22b6b444dcb4a340a120e8213e |
| 出典メモ | uspto-grants-1979_11 |