Ammonia → 2-(3-(1-Oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-5-fluorophenyl)ethanol

HRID 471108ノート

反応式

HRID 471108 の反応式
N.[F:2][C:3]1[CH:4]=[C:5]([CH:31]=[C:32]([CH2:34][CH2:35][OH:36])[CH:33]=1)[CH2:6][N:7]1[CH2:30][CH2:29][C:10]2([O:15][CH2:14][CH2:13][N:12](C(C3N=C(C4C=CC=CC=4)SC=3)=O)[CH2:11]2)[CH2:9][CH2:8]1>CO>[O:15]1[C:10]2([CH2:29][CH2:30][N:7]([CH2:6][C:5]3[CH:31]=[C:32]([CH2:34][CH2:35][OH:36])[CH:33]=[C:3]([F:2])[CH:4]=3)[CH2:8][CH2:9]2)[CH2:11][NH:12][CH2:13][CH2:14]1

参加物

4

反応物 2

HCID 222AmmoniaHCID 57989277(9-(3-Fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-phenylthiazol-4-yl)methanone

生成物 1

HCID 579889902-(3-(1-Oxa-4,9-diazaspiro[5.5]undecan-9-ylmethyl)-5-fluorophenyl)ethanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

‘880’ Ammonia solution (5 mL) was added to a solution of 2,2,2-trifluoro-1-(9-(3-fluoro-5-(2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)ethanone (example 41, step d) (2.2 g) in methanol (25 mL). The resulting mixture was stirred for 90 min and the solvent evaporated. The residue was azeotroped three times with acetonitrile and concentrated to give the subtitled compound as a clear gum. Yield 1.96 g.

後処理

  1. customthe solvent evaporated
  2. customThe residue was azeotroped three times with acetonitrile
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-2960abd10b234dfdbce2f3746f1af1c3
出典データセット
uspto-grants-2014_01
特許番号
US08629271B2

反応ノート

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