2-(4-Chloro-3-(hydroxymethyl)phenyl)ethanol → 2-Chloro-5-(2-hydroxyethyl)benzaldehyde

HRID 471129

反応式

HRID 471129 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][C:3]=1[CH2:11][OH:12]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][C:3]=1[CH:11]=[O:12]

参加物

4

反応物 1

HCID 579892912-(4-Chloro-3-(hydroxymethyl)phenyl)ethanol

生成物 1

HCID 579893312-Chloro-5-(2-hydroxyethyl)benzaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

Manganese (IV) dioxide (1.00 g) was added to a solution of 2-(4-chloro-3-(hydroxymethyl)phenyl)ethanol (example 61, step b) (0.200 g) in DCM (5 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then filtered through Celite, washing the residue well with DCM. The filtrate and washings were concentrated in vacuo to afford the subtitled compound as a colourless oil. Yield 0.197 g.

後処理

  1. filtrationThe mixture was then filtered through Celite
  2. washwashing the residue well with DCM
  3. concentrationThe filtrate and washings were concentrated in vacuo

出典と根拠

ORDレコード
ord-a9012c1578a044dca9dd93736dc3a8ba
出典データセット
uspto-grants-2014_01
特許番号
US08629271B2

関連ノート

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