Ethyl 2-(2,2,2-trifluoroethyl)thiazole-4-carboxylate → 2-(2,2,2-Trifluoroethyl)-1,3-thiazole-4-carboxylic acid
反応式
[F:1][C:2]([F:15])([F:14])[CH2:3][C:4]1[S:5][CH:6]=[C:7]([C:9]([O:11]CC)=[O:10])[N:8]=1>Cl.O>[F:15][C:2]([F:1])([F:14])[CH2:3][C:4]1[S:5][CH:6]=[C:7]([C:9]([OH:11])=[O:10])[N:8]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of ethyl 2-(2,2,2-trifluoroethyl)thiazole-4-carboxylate (example 67, step c) (0.3 g) in concentrated hydrochloric acid (7 mL) and water (7 mL) was heated at 80° C. for 5 hours under nitrogen. The solvent was evaporated under a stream of nitrogen and the residue partitioned between ethyl acetate (40 mL) and brine (3 mL). The organic layer was dried over sodium sulphate, filtered and the solvent evaporated under reduced pressure to afford the subtitled compound. Yield 0.23 g.
後処理
- customThe solvent was evaporated under a stream of nitrogen
- customthe residue partitioned between ethyl acetate (40 mL) and brine (3 mL)
- dry with materialThe organic layer was dried over sodium sulphate
- filtrationfiltered
- customthe solvent evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-3ad11f1093ed4264bb13410edb2826a8
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08629271B2
反応ノート
読み込み中…