2-(2-Chloro-3-(hydroxymethyl)phenyl)ethanol → 2-Chloro-3-(2-hydroxyethyl)benzaldehyde
反応式
[Cl:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][CH2:11][OH:12]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[C:3]([CH2:10][CH2:11][OH:12])=[CH:4][CH:5]=[CH:6][C:7]=1[CH:8]=[O:9]参加物
4
実験手順
Manganese (IV) dioxide (1.599 g) was added to a solution of 2-(2-chloro-3-(hydroxymethyl)phenyl)ethanol (example 80, step c) (0.342 g) in DCM (20 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then concentrated onto silica and purified by flash chromatography on silica eluted with 25% ethyl acetate in isohexane to afford the subtitled compound as a white crystalline solid. Yield 0.223 g.
後処理
- concentrationThe mixture was then concentrated onto silica
- custompurified by flash chromatography on silica
- washeluted with 25% ethyl acetate in isohexane
出典と根拠
- ORDレコード
- ord-025684fe684d4dc29f0e5f9c4b359b8e
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08629271B2
反応ノート
読み込み中…