Ethanol → 4-Dodecyl-2-nitroaniline

HRID 4713ノート

反応式

HRID 4713 の反応式
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:7][C:6]=1[N+:23]([O-:25])=[O:24])(=O)C.C(O)C.[OH-].[K+]>O>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([NH2:4])=[C:6]([N+:23]([O-:25])=[O:24])[CH:7]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

参加物

5

反応物 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 14122183N-acetyl-4-n-dodecyl-2-nitroaniline

生成物 1

HCID 141221844-Dodecyl-2-nitroaniline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a 1-liter flask fitted with a stirrer and reflux condenser, 61.8 grams of N-acetyl-4-n-dodecyl-2-nitroaniline (prepared in Example 2b), 320 ml of ethanol and 64 ml of 40% aqueous potassium hydroxide solution are heated for 1 hour under reflux. The reaction mixture is cooled and then poured into 1.5 liters of water. The crude product is isolated by filtration, washed repeatedly with cold water and recrystallized from methanol. The above-named product is isolated as a solid melting at 69°-71° C. in a yield of 45 grams.

後処理

  1. customIn a 1-liter flask fitted with a stirrer
  2. temperaturereflux condenser
  3. temperatureunder reflux
  4. temperatureThe reaction mixture is cooled
  5. customThe crude product is isolated by filtration
  6. washwashed repeatedly with cold water
  7. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-988f9d1f7f0e4e7b89b7025738b61397
出典データセット
uspto-grants-1988_02
特許番号
US04727158

反応ノート

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