1-[3-acetylthio-2-(methylthiomethyl)propanoyl]-L-proline → [3-mercapto-2-(methylthiomethyl)propanoyl]-L-proline
反応式
[C:1]([S:4][CH2:5][CH:6]([CH2:17][S:18]C)[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C>O.N>[SH:18][CH2:17][CH:6]([CH2:5][S:4][CH3:1])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]参加物
4
実験手順
1-[3-(acetylthio)-2-(methylthiomethyl)propanoyl]-L-proline (1.2 g.) is dissolved in a mixture of water (12 ml.) and concentrated ammonia (12 ml.) under a blanket of argon. After twenty minutes, the reaction mixture is acidified and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness to yield 1-([3-mercapto-2-(methylthiomethyl)propanoyl]-L-proline.
後処理
- waitAfter twenty minutes
- extractionextracted with ethyl acetate
- customThe organic layer is dried
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-cd8b2e9eff664f34b0beda48172fe3a2
- 出典データセット
- uspto-grants-1979_11
- 特許番号
- US04176235
反応ノート
読み込み中…