関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 6-ethyl-5-iodo-1H-pyrimidin-4-one | HCID 178437744 | — |
| 生成物 | 4-Chloro-6-ethyl-5-iodopyrimidine | HCID 10978487 | — |
反応手順
A suspension of 90 g (0.36 mol) 4-hydroxy-5-iodo-6-ethyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (65 g; 67%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08633183B2 |
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| 出典データセット | uspto-grants-2014_01 |
|---|
| ORD ID | ord-6cd1afec87c74639a86a29cbb8cdcfc3 |
|---|
| 出典メモ | uspto-grants-2014_01 |
|---|
