反応式
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[C:9]#[C:10][Si](C)(C)C.C([O-])([O-])=O.[K+].[K+]>CO>[C:9]([C:3]1[CH:4]=[CH:5][C:6]([NH2:8])=[N:7][C:2]=1[CH3:1])#[CH:10]参加物
4
実験手順
The title compound is synthesized according to general procedure GP3 starting from 4.3 g (21.0 mmol) 6-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 1.5 g (10.5 mmol) K2CO3 in 30 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 3.6 g.
後処理
- customThe product is purified by chromatography on silica gel using a DCM/MeOH gradient
出典と根拠
- ORDレコード
- ord-58497208515045d296a66d57ed8c6e9d
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08633183B2
関連ノート
読み込み中…