Benzyl Bromide → 4-Benzyloxy-2-methoxybenzaldehyde

HRID 471428

反応式

HRID 471428 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([O:10][CH3:11])[CH:3]=1.[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([O:10][CH3:11])[CH:3]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 5195414-Hydroxy-2-Methoxybenzaldehyde

生成物 1

HCID 42939904-Benzyloxy-2-methoxybenzaldehyde収率 62.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

4-Hydroxy-2-methoxybenzaldehyde (2.0 g, 13.15 mmol), benzyl bromide (3.14 mL, 26.3 mmol) and potassium carbonate (3.63 g, 26.3 mmol) are combined in acetone (5 mL) and the mixture is stirred for 4 hours. The mixture is concentrated under vacuum, suspended in dichloromethane and washed with water. The organic phase is concentrated under vacuum and the residue purified by flash chromatography (10% ethyl acetate in cyclohexane) to give the title compound (yield 2.0 g).

後処理

  1. concentrationThe mixture is concentrated under vacuum
  2. washwashed with water
  3. concentrationThe organic phase is concentrated under vacuum
  4. customthe residue purified by flash chromatography (10% ethyl acetate in cyclohexane)

出典と根拠

ORDレコード
ord-261053784076497a937144debb75293a
出典データセット
uspto-grants-2014_01
特許番号
US08633182B2

関連ノート

読み込み中…