Diazomethane → Methyl 5-methyl-4-hexenoate

HRID 47160

反応式

HRID 47160 の反応式
[N+](=[CH2:3])=[N-].[CH3:4][C:5]([CH3:12])=[CH:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10]>CCOCC>[CH3:4][C:5]([CH3:12])=[CH:6][CH2:7][CH2:8][C:9]([O:11][CH3:3])=[O:10]

参加物

4

反応物 2

HCID 9550DiazomethaneHCID 124253245-Methyl-4-hexenoic acid

生成物 1

HCID 10909672Methyl 5-methyl-4-hexenoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

Freshly prepared diazomethane in ether was added to an ice-cooled solution of 5-methyl-4-hexenoic acid (4.5 g, 35.16 mmol) in ether (10 mL) until the solution became slightly yellow in color. The solvent was then evaporated under vacuum to afford the title product as a colorless liquid in near quantitative yield (4.90 g). This product was used in the next reaction step without further purification. 1H NMR (CDCl3) δ1.62 & 1.68[2s, 6H, C(CH3)2], 2.30[m, 4H, (CH2)2], 3.69(s, 3H, COOCH3) and 5.07(t, 1H, CH).

後処理

  1. customThe solvent was then evaporated under vacuum

出典と根拠

ORDレコード
ord-32ee0f1e9343437cab24338b7c57f84b
出典データセット
uspto-grants-2004_03
特許番号
US06699458B2

関連ノート

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