Cesium carbonate → ethyl 2-(2-(1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)-4-cyclopentyl-5-hydroxyphenylcarbamoyl)-6-cyano-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate

反応式

Br[C:2]1[CH:7]=[C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)[C:5]([O:13]C(OC)=O)=[CH:4][C:3]=1[NH:18][C:19]([CH:21]1[O:26][C:25]2[CH:27]=[CH:28][C:29]([C:31]#[N:32])=[CH:30][C:24]=2[N:23]([C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH2:22]1)=[O:20].CC1(C)C(C)(C)OB([C:46]2[CH2:47][CH2:48][N:49]([C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[CH2:50][CH:51]=2)O1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:55]([O:54][C:52]([N:49]1[CH2:48][CH:47]=[C:46]([C:2]2[CH:7]=[C:6]([CH:8]3[CH2:12][CH2:11][CH2:10][CH2:9]3)[C:5]([OH:13])=[CH:4][C:3]=2[NH:18][C:19]([CH:21]2[O:26][C:25]3[CH:27]=[CH:28][C:29]([C:31]#[N:32])=[CH:30][C:24]=3[N:23]([C:33]([O:35][CH2:36][CH3:37])=[O:34])[CH2:22]2)=[O:20])[CH2:51][CH2:50]1)=[O:53])([CH3:58])([CH3:56])[CH3:57]