Diethyl Ether → 3-Ethoxycarbonyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

HRID 47217

反応式

HRID 47217 の反応式
[NH2:1][C:2](=[N:8][O:9][C:10]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][C:17]=1[C:18]([F:21])([F:20])[F:19])=O)[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(OCC)C>C1(C)C(C)=CC=CC=1.C1(C)C=CC=CC=1>[CH2:6]([O:5][C:3]([C:2]1[N:1]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][C:17]=2[C:18]([F:21])([F:20])[F:19])[O:9][N:8]=1)=[O:4])[CH3:7]

参加物

5

反応物 2

HCID 3283Diethyl EtherHCID 73994277Ethyl 2-amino-2-(4-trifluormethyl-3-pyridinecarbonyloxyimino)-acetate

生成物 1

HCID 227440743-Ethoxycarbonyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 7237O-Xylene溶媒

実験手順

20 g of ethyl 2-amino-2-(4-trifluormethyl-3-pyridinecarbonyloxyimino)-acetate are dissolved in 200 ml of a mixture of xylene and toluene and admixed with 5 g of Amberlyst 15. The mixture is boiled at 125-130° C. for 6 h using a Dean-Stark apparatus. After the reaction has ended, the mixture is cooled and admixed with a small amount of diethyl ether. The mixture is filtered with suction through a glass filter frit, and the solution is then concentrated. This gives 15.8 g of the product as a yellow oil.

後処理

  1. customfor 6 h
  2. temperaturethe mixture is cooled
  3. filtrationThe mixture is filtered with suction through a glass
  4. filtrationfilter frit
  5. concentrationthe solution is then concentrated

出典と根拠

ORDレコード
ord-e9a27cfcb86a4e179942c262d9c4839d
出典データセット
uspto-grants-2004_03
特許番号
US06699853B2

関連ノート

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