Hydrochloric Acid → 3-fluoro-6,10b-dihydro-1aH-dibenzo-[3,4:6,7]cyclohept[1,2-b]oxirene
反応式
[F:1][C:2]1[CH:16]=[CH:15][C:5]2[CH2:6][C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH:9]=[CH:10][C:4]=2[CH:3]=1.Cl.Cl.CC([OH:22])C>C(OCC)C>[F:1][C:2]1[CH:16]=[CH:15][C:5]2[CH2:6][C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[CH:9]3[O:22][CH:10]3[C:4]=2[CH:3]=1参加物
5
実験手順
Compound 1 was dissolved in diethyl ether (20 ml) and converted into the hydrochloric acid salt (1:1) by dropwise addition of 6 N HCl/2-propanol. The solvent was evaporated. The residue was triturated under boiling 2-propanone, filtered off and dried, yielding 2.17 g (43%) of (±)-(2α,3aβ,12bα)-11-fluoro-3,3a,8,12b-tetrahydro-N, N-dimethyl-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan-2-methanamine hydrochloride (compound 2; mp. 239.1° C.).
後処理
- customThe solvent was evaporated
- customThe residue was triturated under boiling 2-propanone
- filtrationfiltered off
- customdried
出典と根拠
- ORDレコード
- ord-26278836630c419db0cc219d547fda6f
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06699858B2
反応ノート
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