6-Bromo-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene → [8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-amine

HRID 472282

反応式

HRID 472282 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]3[N:13]([N:17]=[C:18]([NH2:20])[N:19]=3)[CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].Br[C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[C:28]([CH3:33])([CH3:32])[CH2:27][CH2:26][C:25]2([CH3:35])[CH3:34]>>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]3[N:13]([N:17]=[C:18]([NH:20][C:31]4[CH:22]=[CH:23][C:24]5[C:25]([CH3:35])([CH3:34])[CH2:26][CH2:27][C:28]([CH3:33])([CH3:32])[C:29]=5[CH:30]=4)[N:19]=3)[CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)(=[O:3])=[O:4]

参加物

3

反応物 2

HCID 2266856-Bromo-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthaleneHCID 575023768-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

生成物 1

HCID 67481396[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-amine

実験手順

[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-amine was prepared from 8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (100.0 mg, 0.3468 mmol) and 6-bromo-1,1,4,4-tetramethyl-1,2,3,4-tetrahydro-naphthalene (140.0 mg, 0.5239 mmol) in a manner analogous to Step 2d and was isolated as a yellow foam (0.049 g, 30%). 1H NMR (400 MHz, CDCl3, δ, ppm): 8.47 (dd, J=6.7, 1.1 Hz, 1H), 8.29-8.25 (m, 2H), 8.10-8.05 (m, 2H), 7.65 (dd, J=7.5, 1.2 Hz, 1H), 7.57 (d, J=2.3 Hz, 1H), 7.36-7.27 (m, 2H), 7.00 (dd, J=7.2, 7.2 Hz, 1H), 6.76 (s, 1H), 3.10 (s, 3H), 1.74-1.66 (m, 4H), 1.33 (s, 6H), 1.28 (s, 6H). MS=475 (MH)+.

出典と根拠

ORDレコード
ord-56dc04df7b054554b008b63ee631c9f1
出典データセット
uspto-grants-2014_01
特許番号
US08633173B2

関連ノート

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