2-Chloro-5-(trifluoromethyl)phenylboronic acid → 2-Chloro-8-(2-chloro-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

反応式

Br[C:2]1[C:3]2[N:4]([N:8]=[C:9]([Cl:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=1B(O)O>>[Cl:11][C:9]1[N:10]=[C:3]2[C:2]([C:14]3[CH:15]=[C:16]([C:19]([F:21])([F:22])[F:20])[CH:17]=[CH:18][C:13]=3[Cl:12])=[CH:7][CH:6]=[CH:5][N:4]2[N:8]=1

参加物

反応物 2

HCID 27826702-Chloro-5-(trifluoromethyl)phenylboronic acid

HCID 674813708-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine

生成物 1

HCID 674789062-Chloro-8-(2-chloro-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

実験手順

2-Chloro-8-(2-chloro-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine was prepared from 8-bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine (0.50 g, 2.15 mmol) and 2-chloro-5-trifluoromethylphenylboronic acid (0.72 g, 3.23 mmol) in a manner analogous to Example 2c (0.115 g, 16%). MP=156-158° C. MS=332 (MH)+.

出典と根拠

ORDレコード: ord-5706f03fa8d84bdb8689a70dd609ecd0
出典データセット: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08633173B2

反応ノート

読み込み中…