1-(4-Fluorophenyl)pyrazole-4-boronic acid → [1-(4-fluoro-phenyl)1H-pyrazol-4-yl]-[1,2,4]triazolo[1,5-a]pyridine

反応式

Br[C:2]1[C:3]2[N:4]([N:8]=[C:9](Cl)[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]2[CH:23]=[C:22](B(O)O)[CH:21]=[N:20]2)=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:14]=[CH:15][C:16]([N:19]2[CH:23]=[C:22]([C:9]3[N:10]=[C:3]4[CH:2]=[CH:7][CH:6]=[CH:5][N:4]4[N:8]=3)[CH:21]=[N:20]2)=[CH:17][CH:18]=1

参加物

反応物 2

HCID 467386841-(4-Fluorophenyl)pyrazole-4-boronic acid

HCID 674813708-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine

生成物 1

HCID 86648363[1-(4-fluoro-phenyl)1H-pyrazol-4-yl]-[1,2,4]triazolo[1,5-a]pyridine

実験手順

2-Chloro-8-([1-(4-fluoro-phenyl)1H-pyrazol-4-yl]-[1,2,4]triazolo[1,5-a]pyridine was prepared from 8-bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyridine and 1-(4-fluorophenyl)pyrazole-4-boronic acid in a manner analogous to Example 2c (0.45 g, 67%).

出典と根拠

ORDレコード: ord-165ce9346f0f487e81a91cf5f4cc56dc
出典データセット: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08633173B2

反応ノート

読み込み中…