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tert-Butoxy bis(dimethylamino)methane → 4-(3-Dimethylamino-2-phenyl-acryloyl)-1H-pyrrole-2-carboxylic acid benzylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| 反応物 | 4-Phenylacetyl-1H-pyrrole-2-carboxylic acid benzylamide | HCID 12125417 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(3-Dimethylamino-2-phenyl-acryloyl)-1H-pyrrole-2-carboxylic acid benzylamide | HCID 69426886 | — |
反応手順
To a solution of compound 2 (1 equivalent) in THF, at ambient temperature, was added (Me2N)2CHOt-Bu (3 equivalents). After 24 hours, the solvent was evaporated and the crude product 3 was utilized without purification. 1H NMR (CDCl3) δ4.4 (s, 2H), 4.8 (s, NH), 6.8-7.4 (m, 13H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699865B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-7f59283adf5042a7898d3252250cc88f |
| 出典メモ | uspto-grants-2004_03 |