6-Methoxy-3-pyridinylamine → N(8)-(2-Methoxy-benzyl)-N(2)-(6-methoxy-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine

HRID 472659

反応式

HRID 472659 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.Cl[C:11]1[N:29]=[C:14]2[C:15]([NH:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][CH3:28])=[CH:16][CH:17]=[CH:18][N:13]2[N:12]=1>>[CH3:28][O:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[CH2:20][NH:19][C:15]1[C:14]2[N:13]([N:12]=[C:11]([NH:1][C:2]3[CH:7]=[N:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=3)[N:29]=2)[CH:18]=[CH:17][CH:16]=1

参加物

3

反応物 2

HCID 811216-Methoxy-3-pyridinylamineHCID 67479414(2-Chloro-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-(2-methoxy-benzyl)-amine

生成物 1

HCID 59612507N(8)-(2-Methoxy-benzyl)-N(2)-(6-methoxy-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine

実験手順

N(8)-(2-Methoxy-benzyl)-N(2)-(6-methoxy-pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridine-2,8-diamine was prepared from 5-amino-2-methoxypyridine (96.31 mg, 0.7758 mmol) and (2-Chloro-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-(2-methoxy-benzyl)-amine (200.00 mg, 0.69268 mmol) in a manner analogous to Example 2d. Product isolated as a red foam (41.05 mg, 16%). 1H NMR (400 MHz, (D3C)2SO, δ, ppm): 9.31 (s, 1H), 8.58 (s, 1H), 8.04 (d, J=9.3 Hz, 1H), 7.93 (d, J=6.8 Hz, 1H), 7.24 (m, 2H), 7.02 (d, J=8.4 Hz, 1H), 6.87 (t, J=14.9, 7.2 Hz, 1H), 6.78 (d, J=9.4 Hz, 1H), 6.72 (t, J=14.9, 7.2 Hz, 1H), 6.29 (m, 2H), 4.45 (d, J=6.0 Hz, 2H), 3.87 (s, 3H), 3.81 (s, 3H). MS=377 (MH)+.

出典と根拠

ORDレコード
ord-39b29dec9df543ea87f90bb6bc33a738
出典データセット
uspto-grants-2014_01
特許番号
US08633173B2

関連ノート

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