Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro- → HCID 136397840、化合物

HRID 47267ノート

反応式

HRID 47267 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:13][CH3:14].[NH:15]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[C@H:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=2)=[CH:19][CH:18]=1)[NH2:16]>C(O)C>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[N:16][NH:15][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[C@H:24]([CH3:30])[CH2:25][C:26](=[O:29])[NH:27][N:28]=3)=[CH:19][CH:18]=2)=[C:4]([N+:10]([O-:12])=[O:11])[C:3]=1[O:13][CH3:14]

参加物

4

反応物 2

HCID 96959Benzaldehyde, 4-hydroxy-3-methoxy-2-nitro-HCID 69529174(R)-6-(4-hydrazino-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one

生成物 1

HCID 136397840HCID 136397840、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A solution of 4-hydroxy-3-methoxy-2-nitro-benzaldehyde (1.6 g) in ethanol (15 ml) was added to a suspension of (R)-6-(4-hydrazino-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one (1.75 g) in ethanol (20 ml) and the resulting mixture refluxed for two hours. The resulting crystals were filtered at room temperature and washed with ethanol. Yield 2.37 g. HPLC: purity 99.4%, optical purity 99.8%.

後処理

  1. temperaturethe resulting mixture refluxed for two hours
  2. filtrationThe resulting crystals were filtered at room temperature
  3. washwashed with ethanol

出典と根拠

ORDレコード
ord-b9d0cf976a794ddeb6ba1b5f4e6d51f5
出典データセット
uspto-grants-2004_03
特許番号
US06699868B2

反応ノート

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