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Cyclopentylamine → N-(5-Chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide

HRID 472742
ノート
印刷プレビュー

反応式

HRID 472742 の反応式
[Cl:1][C:2]1[C:3]([O:29][CH3:30])=[CH:4][C:5]([O:27][CH3:28])=[C:6]([NH:8][C:9]([CH2:11][N:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][N:14]([CH2:22][C:23](O)=[O:24])[C:13]2=[O:26])=[O:10])[CH:7]=1.CN(C(ON1N=N[C:41]2[CH:42]=[CH:43][CH:44]=[N:45][C:40]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C1(N)CCCC1>CS(C)=O>[Cl:1][C:2]1[C:3]([O:29][CH3:30])=[CH:4][C:5]([O:27][CH3:28])=[C:6]([NH:8][C:9](=[O:10])[CH2:11][N:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][N:14]([CH2:22][C:23](=[O:24])[NH:45][CH:40]3[CH2:41][CH2:42][CH2:43][CH2:44]3)[C:13]2=[O:26])[CH:7]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 2906CyclopentylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 59317691{1-[(5-Chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2-oxo-1,4-dihydro-2H-quinazolin-3-yl}-acetic acid

生成物 1

HCID 59317677N-(5-Chloro-2,4-dimethoxy-phenyl)-2-(3-cyclopentylcarbamoylmethyl-2-oxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamide

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒2 回

実験手順

A solution of {1-[(5-chloro-2,4-dimethoxy-phenylcarbamoyl)-methyl]-2-oxo-1,4-dihydro-2H-quinazolin-3-yl}-acetic acid (Example 5-1) (20 mg, 0.046 mmol) in DMSO (1 ml) is treated with a solution of HATU (19.3 mg, 0.05 mmol) in DMSO (2 ml). The reaction mixture is then treated with cyclopentylamine (4.12 mg, 0.048 mmol) and the reaction left to stand at RT overnight. The reactions are analysed by HPLC/LCMS and concentrated in vacuo. The residue is taken up in DCM and washed with 1M HCl The organic phase is washed with saturated NaHCO3 and concentrated in vacuo to give the title compound; [M+H]+ 501

後処理

  1. waitthe reaction left
  2. concentrationconcentrated in vacuo
  3. washwashed with 1M HCl The organic phase
  4. washis washed with saturated NaHCO3
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-d08f9af85b174625986c9bd38fc82c06
出典データセット
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08633211B2

反応ノート

読み込み中…

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