化工社化工社 化学情報印刷レポート · 研究参考用
4-Methylmorpholine → Boc-Val-Pro-OBzl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | Boc-L-Valine | HCID 83693 | — |
| 反応物 | Benzyl L-prolinate | HCID 736155 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Boc-Val-Pro-OBzl | HCID 14304307 | — |
反応手順
Boc-Val-Pro-OBzl was prepared by dissolving H-Pro-OBzl (20 g, 83 mmol) in 50 mL of chloroform and adding Boc-Val-OH (18.0 g, 83 mmol), HOBt (23.0g, 165 mmol), NMM ( 9.0 mL, 83 mmol) and DCC (17.0 g, 83 mmol). The reaction mixture was stirred overnight at room temperature. The mixture was filtered and solvent was evaporated. Ethyl acetate was added and insoluble material was removed by filtration. The filtrate was washed with 0.2N HCl, 5% NaHCO3, and saturated aqueous NaCl. It was dried over Na2SO4, filtered and evaporate to give a white solid (30 g, 75 mmol, 90%). ESI/MS calculated for C22H32N2O5 +H: 405.2. Found 405.6.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699855B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-875dcea2b1ff48fba32f631ed9d15f10 |
| 出典メモ | uspto-grants-2004_03 |