Methanol → 2-(4,5-dihydro-1H-imidazol-2-yl)benzenethiol
反応式
[C:1](O)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].[CH2:11]([NH2:14])[CH2:12][NH2:13].CO>ClC1C=CC=CC=1Cl>[NH:13]1[CH2:12][CH2:11][N:14]=[C:1]1[C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[SH:4]参加物
5
反応条件
- 温度
- 60 °C
実験手順
To a suspension of 20.0 g (0.112 mol) of thiosalicylic acid in 200 mL of 1,2-dichlorobenzene was added 21.6 mL (0.323 mol) of ethylenediamine. The mixture was refluxed under nitrogen for 4 h then cooled to ca. 60° C. and 50 mL of methanol was added. The solution was allowed to stand at 22° C. over night and the resulting yellow crystalline solid collected and washed with ether to give 10.6 g of pure product.
後処理
- temperatureThe mixture was refluxed under nitrogen for 4 h
- waitto stand at 22° C. over night
- customthe resulting yellow crystalline solid collected
- washwashed with ether
出典と根拠
- ORDレコード
- ord-4a87912f4f5b4b53b7be1e8d5a52c856
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06699873B1
反応ノート
読み込み中…