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Triacetoxyperiodinane → Ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

HRID 472881
ノート
印刷プレビュー

反応式

HRID 472881 の反応式
[Cl:1][C:2]1[N:7]2[N:8]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=3)[C:10]([CH3:11])=[C:6]2[N:5]=[C:4]([CH3:19])[C:3]=1[CH:20]([OH:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl.CCOC(C)=O>[Cl:1][C:2]1[N:7]2[N:8]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=3)[C:10]([CH3:11])=[C:6]2[N:5]=[C:4]([CH3:19])[C:3]=1[C:20](=[O:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 159087TriacetoxyperiodinaneHCID 86670291Ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

生成物 1

HCID 86670292Ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate収率 72.4%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857
Ethyl Acetate
溶媒

実験手順

To a solution of ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate (5.4 g, 12.33 mmol) in CH2Cl2 (100 ml) was added Dess-Martin periodinane (5.75 g, 13.56 mmol). The reaction was stirred 1 hr, then diluted with EtOAc (600 mL) and washed with saturated aqueous NaHCO3 (200 mL). The organic layer was then dried (NaHSO4), filtered, and concentrated. The residue was triturate with Et2O, stirring vigorously for 30 min, collecting solids by vacuum. The semi-pure product was purified by flash silica gel column and eluted with 10-20% EtOAc in hexanes, affording the product, ethyl 2-(7-chloro-2-(3-chlorophenyl)-3,5-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate (3.5 g, 8.92 mmol, 72.4% yield) as a pale yellow solid. 1H NMR (500 MHz, CDCl3) δ: 7.89-7.86 (m, 1H), 7.78-7.73 (m, 1H), 7.45-7.41 (m, 2H), 4.45 (q, J=7.1 Hz, 2H), 2.63 (s, 3H), 2.53 (s, 3H), 1.42 (t, J=7.2 Hz, 3H). LCMS (M+H)=392.1.

後処理

  1. washwashed with saturated aqueous NaHCO3 (200 mL)
  2. dry with materialThe organic layer was then dried (NaHSO4)
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe residue was triturate with Et2O
  6. stirringstirring vigorously for 30 min
  7. customcollecting solids by vacuum
  8. customThe semi-pure product was purified by flash silica gel column
  9. washeluted with 10-20% EtOAc in hexanes

出典と根拠

ORDレコード
ord-659ef1387f314ba085f8f4744b395d7f
出典データセット
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08633200B2

反応ノート

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