Formic Acid → 8-(Benzyloxy)imidazo[1,5-a]pyridine

反応式

[CH2:1]([O:8][C:9]1[C:10]([CH2:15][NH2:16])=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O.[CH:22](O)=O>>[CH2:1]([O:8][C:9]1[C:10]2[N:11]([CH:22]=[N:16][CH:15]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

反応物 3

HCID 284Formic Acid

HCID 24813Phosphorus oxychloride

HCID 12074949HCID 12074949、化合物

生成物 1

HCID 454896908-(Benzyloxy)imidazo[1,5-a]pyridine

実験手順

This compound is prepared according to the same procedure as in preparation II (stage C) from 2.8 g (13.25 mmol) of 1-[3-(benzyloxy)pyridin-2-yl]methanamine [described in Inorg. Chem., (2003), 42(14), 4401] by formylation with formic acid and then cyclization by reaction with phosphoryl chloride. 1.74 g of a brown oil are obtained.

後処理

customThis compound is prepared

出典と根拠

ORDレコード: ord-1f5568f766304aa78c6458f8d07aab3a
出典データセット: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08633216B2

反応ノート

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