Potassium Hydroxide → 2-(4-Bromobenzyl)malonic acid
反応式
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][CH:7]([C:13]([O:15]CC)=[O:14])[C:8]([O:10]CC)=[O:9])=[CH:4][CH:3]=1.[OH-].[K+]>OC(C)=O.O.C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([C:8]([OH:10])=[O:9])[C:13]([OH:15])=[O:14])=[CH:18][CH:19]=1参加物
4
実験手順
Diethyl 2-(4-bromobenzyl)malonate (40 g, 13 mmol) and KOH (42.8 g, 76 mmol) was dissolved in a mixture of HOAc-H2O-THF (1:2:3, 200 mL), the mixture was refluxed for 12 hours. The solvent was removed in vacuo, the residue was added HCl aqueous, then extracted with EtOAc, washed with brine, dried over Na2SO4, concentrated to give 2-(4-bromobenzyl)malonic acid (31 g, 95%).
後処理
- temperaturethe mixture was refluxed for 12 hours
- customThe solvent was removed in vacuo
- additionthe residue was added HCl aqueous
- extractionextracted with EtOAc
- washwashed with brine
- dry with materialdried over Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-01c7f3098df2413bb1bdfff583d7c8cd
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08633212B2
反応ノート
読み込み中…