Hydrochloric Acid → 4-Methoxy-3-(trifluoromethyl)benzylamine hydrochloride
反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([CH2:7][NH:8]C=O)=[CH:5][C:4]=1[C:13]([F:16])([F:15])[F:14].[ClH:17].C(OCC)C>C(O)C>[ClH:17].[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([CH2:7][NH2:8])=[CH:5][C:4]=1[C:13]([F:14])([F:15])[F:16]参加物
5
実験手順
3.8 g of N-[4-methoxy-3-(trifluoromethyl)benzyl]formamide was dissolved in 20 ml ethanol, 2 ml conc. hydrochloric acid was added thereto, and the mixture was heated under reflux for 3 hr. After cooling, diethyl ether was added thereto, and the resulting crystals were collected by filtration to give 2.5 g of 4-methoxy-3-(trifluoromethyl)benzylamine hydrochloride.
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 3 hr
- temperatureAfter cooling
- filtrationthe resulting crystals were collected by filtration
出典と根拠
- ORDレコード
- ord-6d6291f394684e2fb7328e9ec108a50f
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06699870B2
反応ノート
読み込み中…