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HRID 473427作成日：2026年10月26日
Cerium trichloride heptahydrate → Methyl 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate
https://huagongshe.com/reaction/473427
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cerium trichloride heptahydrate | HCID 21585214 | — |
| 反応物 | Methyl 3-(2-(methylsulfonyl)phenyl)-3-oxopropanoate | HCID 58318596 | — |
| 反応物 | 3-Amino-5-fluoropyridine-2-carbaldehyde | HCID 58318647 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate | HCID 67239501 | — |
反応手順
A mixture of 3-amino-5-fluoropicolinaldehyde (930 mg, 6.63 mmol), methyl 3-(2-(methylsulfonyl)phenyl)-3-oxopropanoate (1.7 g, 6.63 mmol) and cerium chloride heptahydrate (435 mg, 1.32 mmol) was heated to 100° C. for 3 h. The residue was dissolved in MeOH and purified by column chromatography on neutral alumina using 0-30% EtOAc in hexane to give methyl 7-fluoro-2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridine-3-carboxylate: LC-MS (ESI) m/z 361.0 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08633313B2 |
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| 出典データセット | uspto-grants-2014_01 |
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| ORD ID | ord-dcebcd8a05e140ac8c25b09b70a04a8f |
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| 出典メモ | uspto-grants-2014_01 |
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