p-Toluenesulfonic acid monohydrate → HCID 45280693、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[CH:10]=[CH:11][C:12]2[C:18](=[O:19])[C:17]3[CH:20]=[CH:21][CH:22]=[C:23]([O:24][CH2:25][C@H:26]4[CH2:30][O:29]C(C)(C)[O:27]4)[C:16]=3[CH2:15][CH2:14][C:13]=2[CH:33]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO.O>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[CH:10]=[CH:11][C:12]2[C:18](=[O:19])[C:17]3[CH:20]=[CH:21][CH:22]=[C:23]([O:24][CH2:25][C@H:26]([OH:27])[CH2:30][OH:29])[C:16]=3[CH2:15][CH2:14][C:13]=2[CH:33]=1参加物
5
実験手順
For the synthesis of the title compound, 0.10 g (0.225 mmol) of (S)-8-(2-aminophenylamino)-1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-10,11-dihydrodibenzo[a,d]cyclohepten-5-one and 0.0537 g (0.282 mmol) of p-toluenesulfonic acid monohydrate in 6 ml of methanol and 1.5 ml of water are reacted by method N. C24H24N2O4 (Mr=404.47); yield: 40%