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1-(4-Fluorophenyl)-1h-indole-5-carboxylic acid → 4-(1-{[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-pyrimidin-2-ylpiperazin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Fluorophenyl)-1h-indole-5-carboxylic acid | HCID 22603071 | — |
| 反応物 | 3-(3-Oxo-4-pyrimidin-2-yl-piperazin-1-yl)-azetidine-1-carboxylic acid tert-butyl ester | HCID 66836249 | — |
| 生成物 | 4-(1-{[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl}azetidin-3-yl)-1-pyrimidin-2-ylpiperazin-2-one | HCID 66823546 | — |
反応手順
Cpd 4 was prepared according to the procedures described in Example 2, Step D, using intermediates 3c and 1-(4-fluoro-phenyl)-1H-indole-5-carboxylic acid 3h as starting materials. MS 471 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08637498B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-5eacd61f07dd4dbc975932ebc478116b |
| 出典メモ | uspto-grants-2014_01 |