化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → 5,7-Dichloro-4-p-tolyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 1-Ethenyl-4-methylbenzene | HCID 12161 | — |
| 反応物 | 3,5-Dichloroaniline | HCID 12281 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Ketobutyrate | HCID 3593277 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 5,7-Dichloro-4-p-tolyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid | HCID 9902295 | — |
反応手順
Compound 20 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-methylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699877B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-a143d2b5e5ac4c2996929dc839306c84 |
| 出典メモ | uspto-grants-2004_03 |