化工社化工社 化学情報印刷レポート · 研究参考用
Promethazine → promethazine dibenzoyl-D-tartrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Promethazine | HCID 4927 | — |
| 反応物 | Di-benzoyl-d-tartaric acid | HCID 12362977 | — |
| 反応物 | promethazine D-tartrate | HCID 86609044 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | promethazine dibenzoyl-D-tartrate | HCID 131731159 | — |
反応手順
To prepare promethazine-D-tartrate, promethazine (10 g, 0.035 mol) dissolved in 80 ml acetone was heated in a 60° C. bath while dibenzoyl-D-tartaric acid (12.789 g, 0.036 mol) was added. The resulting clear yellow solution was left at ambient temperature for 3 days (step 2). A heavy precipitate formed, which was filtered off and recrystalized from ethanol four times to give 4.0 g promethazine dibenzoyl-D-tartrate white crystals (step 3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08637503B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-f0c06199abd84d49a9fcb7be2f20aa78 |
| 出典メモ | uspto-grants-2014_01 |