Hydrochloric Acid → 4-(Methylsulfanyl)piperidine hydrochloride

HRID 473803ノート

反応式

HRID 473803 の反応式
[CH3:1][S:2][CH:3]1[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1.[ClH:16]>CO.O1CCOCC1>[ClH:16].[CH3:1][S:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 11053478Tert-butyl 4-(methylthio)piperidine-1-carboxylate

生成物 1

HCID 509989504-(Methylsulfanyl)piperidine hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of tert-butyl 4-(methylthio)piperidine-1-carboxylate (63 mg, 0.27 mmol) in methanol (1 mL) and 4 N hydrogen chloride in dioxane (4 mL) was refluxed for 2 min and then concentrated and dried to provide 4-(methylthio)piperidine hydrochloride as a colorless oil.

後処理

  1. concentrationconcentrated
  2. customdried

出典と根拠

ORDレコード
ord-bf18d89f947e418da75f772f78ba9115
出典データセット
uspto-grants-2014_01
特許番号
US08637499B2

反応ノート

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