化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → 5,7-dichloro-4-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 3,5-Dichloroaniline | HCID 12281 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Fluorostyrene | HCID 67883 | — |
| 反応物 | 2-Ketobutyrate | HCID 3593277 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 5,7-dichloro-4-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid | HCID 10268807 | — |
反応手順
Compound 31 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-fluorostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699877B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-7d9f40e18fc944c8bf14f9aff652b312 |
| 出典メモ | uspto-grants-2004_03 |