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4-Nitrophenol → HCID 131731165、化合物

HRID 474176
ノート
印刷プレビュー

反応式

HRID 474176 の反応式
[NH:1]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C@H:2]([C:4]([NH:6][C@H:7]([C:20]([OH:22])=[O:21])[CH2:8][CH2:9][C:10](=[O:19])[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:5])[CH3:3].[CH:30]1[C:35]([N+:36]([O-:38])=[O:37])=[CH:34][CH:33]=[C:32](O)[CH:31]=1.C1CCC(N=C=NC2CCCCC2)CC1>CCOC(C)=O>[NH:1]([C:23]([O:25][C:26]([CH3:28])([CH3:27])[CH3:29])=[O:24])[C@H:2]([C:4]([NH:6][C@H:7]([C:20]([O:22][C:32]1[CH:31]=[CH:30][C:35]([N+:36]([O-:38])=[O:37])=[CH:34][CH:33]=1)=[O:21])[CH2:8][CH2:9][C:10](=[O:19])[O:11][CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:5])[CH3:3]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 9804-NitrophenolHCID 10868DicyclohexylcarbodiimideHCID 124669052Boc-Ala-Glu(OBzl)-OH

生成物 1

HCID 131731165HCID 131731165、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
0 °C

実験手順

Boc-L-Ala-L-Glu(OBzl)-OH (40.5 g, 0.1 mol) was dissolved in 300 ml of EtOAc and combined with 17 g (0.12 mol) of p-nitrophenol. The reaction was kept at 0° C. for 1 hour. DCC (24.7 g, 0.12 mol) was then added. The reaction was stirred for 1 hour at 0° C. and for 4 hours at room temperature. The precipitate of DCU was filtered off and the solvent was evaporated in vacuum. The residual oil was then dissolved in ether. The precipitate was filtered off and washed with ether and hexane. The yield was 35 g (64%). Rf=0.7 (CHCl3:Et-Ac:MeOH=6:3:1).

後処理

  1. filtrationThe precipitate of DCU was filtered off
  2. customthe solvent was evaporated in vacuum
  3. dissolutionThe residual oil was then dissolved in ether
  4. filtrationThe precipitate was filtered off
  5. washwashed with ether and hexane

出典と根拠

ORDレコード
ord-67fbb46a1bef4cfcb6d08b3efc560361
出典データセット
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08637521B2

反応ノート

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