Hydrochloric Acid → HCID 178503525、化合物

HRID 474298ノート

反応式

HRID 474298 の反応式
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][C:5]1[S:6][C:7]2[N:8]=[C:9]([S:17][CH3:18])[N:10]=[C:11]([O:14]CC)[C:12]=2[N:13]=1.O1CCOCC1.Cl>O>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:3]=1[CH2:4][C:5]1[S:6][C:7]2[N:8]=[C:9]([S:17][CH3:18])[N:10]=[C:11]([OH:14])[C:12]=2[N:13]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-Dioxane2 回HCID 685191702-(2,6-Dichloro-benzyl)-7-ethoxy-5-methylsulfanyl-thiazolo[5,4-d]pyrimidine

生成物 1

HCID 178503525HCID 178503525、化合物収率 62.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

To a mixture of 2-(2,6-dichloro-benzyl)-7-ethoxy-5-methylsulfanyl-thiazolo[5,4-d]pyrimidine (1.7 g, 4.4 mmol), 1,4-dioxane (20 mL), and H2O (4 mL) was added 4 N HCl in dioxane (13 mmol, 3.3 mL) and the resulting solution was heated to 90° C. After 12 h, the solution was cooled and concentrated. The resulting residue was purified by FCC to afford the title compound (980 mg, 62%).

後処理

  1. temperaturethe solution was cooled
  2. concentrationconcentrated
  3. customThe resulting residue was purified by FCC

出典と根拠

ORDレコード
ord-3c6be2d1b87b4343bf5b5552c6aa34df
出典データセット
uspto-grants-2014_01
特許番号
US08637527B2

反応ノート

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