Methanol → 2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl ester

HRID 47437ノート

反応式

HRID 47437 の反応式
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([O:7][C:8]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:9]=2[C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[CH3:22]O>S(=O)(=O)(O)O>[CH3:22][O:11][C:10](=[O:12])[C:9]1[CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=[CH:16][C:8]=1[O:7][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 887MethanolHCID 28008662-(4-methoxyphenoxy)-5-nitrobenzoic acid

生成物 1

HCID 540755342-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl ester

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid (2.5 g), (DE 2058295) in methanol (75 ml) containing conc. sulfuric acid (3 drops) was boiled for 16 h. Solvent was removed at reduced pressure, the residue dissolved in ethyl acetate and washed with aqueous sodium hydrogen carbonate. The organic phase was dried (Na2SO4) and solvent removed at reduced pressure to give 2-(4-methoxy-phenoxy)-5-nitro-benzoic acid methyl ester (2.50 g). m/z (API+): 304 (MH+).

後処理

  1. customSolvent was removed at reduced pressure
  2. dissolutionthe residue dissolved in ethyl acetate
  3. washwashed with aqueous sodium hydrogen carbonate
  4. dry with materialThe organic phase was dried (Na2SO4) and solvent
  5. customremoved at reduced pressure

出典と根拠

ORDレコード
ord-fcd65e698cba4ce88f7661c0861eb09c
出典データセット
uspto-grants-2004_03
特許番号
US06699879B1

反応ノート

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