Hydrochloric Acid → HCID 66763587、化合物

HRID 474383ノート

反応式

HRID 474383 の反応式
[CH3:1][O:2][CH2:3][CH2:4][CH:5]([NH:15]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1.Cl>CO>[CH3:1][O:2][CH2:3][CH2:4][CH:5]([NH2:15])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68096871HCID 68096871、化合物

生成物 1

HCID 66763587HCID 66763587、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of tert-butyl [3-methoxy-1-(3-nitrophenyl)propyl]carbamate (1.5 g; 4.83 mmol; 1.00 eq.) in MeOH (2 mL) was added hydrogen chloride (12.08 ml; 4.00 M; 48.33 mmol; 10.00 eq.). The mixture was stirred for 2 h. After removal of the solvent, the residue was diluted with EtOAc, washed with K2CO3 solution, dried and concentrated. The crude product (1.0 g) was used as such for the next reaction without purification. LCMS [211 (M+1)].

後処理

  1. customAfter removal of the solvent
  2. additionthe residue was diluted with EtOAc
  3. washwashed with K2CO3 solution
  4. customdried
  5. concentrationconcentrated
  6. customsuch for the next reaction
  7. customwithout purification

出典と根拠

ORDレコード
ord-d1426ffea9494f66b15f8bd7819bad88
出典データセット
uspto-grants-2014_01
特許番号
US08637532B2

反応ノート

読み込み中…