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Cyclopropanemethanamine → N-cyclopropylmethyl-2-methoxy-5-nitrobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclopropanemethanamine | HCID 75646 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | 2-Methoxy-5-nitrobenzoic acid | HCID 284163 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-cyclopropylmethyl-2-methoxy-5-nitrobenzamide | HCID 22745177 | — |
反応手順
A solution of 2-methoxy-5-nitrobenzoic acid (4.9 g) (Rec. Trav. Chim. Pays-Bas, 1936, 737) and cyclopropylmethylamine (1.75 g) in dimethylformamide was treated with N-hydroxybenzotriazole (0.2 g) and EDC.HCl (4.74 g). The mixture was stirred for 24 h. Saturated sodium hydrogen carbonate was added, the mixture stirred for 3 h and the precipitate collected as the title compound (6.95 g). m/z (API+): 251 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699879B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-3370e82ed778478a89ecbc5d7a072618 |
| 出典メモ | uspto-grants-2004_03 |