4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride → HCID 178513604、化合物

HRID 474471

反応式

HRID 474471 の反応式
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=1)[CH2:6][NH:7][C:8]1[C:17]2[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][N:9]=1.Cl[C:25]1[NH:29][C:28]2[CH:30]=[CH:31][C:32]([C:34]([F:37])([F:36])[F:35])=[CH:33][C:27]=2[N:26]=1>CN(C=O)C>[F:37][C:34]([F:35])([F:36])[C:32]1[CH:31]=[CH:30][C:28]2[NH:29][C:25]([NH:2][C:3]3[CH:4]=[C:5]([CH:21]=[CH:22][CH:23]=3)[CH2:6][NH:7][C:8]3[C:17]4[C:12](=[C:13]([C:18]([NH2:20])=[O:19])[CH:14]=[CH:15][CH:16]=4)[N:11]=[CH:10][N:9]=3)=[N:26][C:27]=2[CH:33]=1

参加物

4

反応物 2

HCID 667633584-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochlorideHCID 178506089HCID 178506089、化合物

生成物 1

HCID 178513604HCID 178513604、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

33 mg (0.11 mmol) 4-(3-Amino-benzylamino)-quinazoline-8-carboxylic acid amide hydrochloride and 24 mg (0.11 mmol) 2-Chloro-5-trifluoromethyl-1H-benzoimidazole were dissolved in 500 μl DMF and stirred at 100° C. for 15 h. The reaction mixture was directly purified using preparative HPLC. The product was treated with HCl in methanol and concentrated in the SpeedVac.

後処理

  1. customThe reaction mixture was directly purified
  2. additionThe product was treated with HCl in methanol
  3. concentrationconcentrated in the SpeedVac

出典と根拠

ORDレコード
ord-b73afaaeb5fb4c2298486c853c8e7c6f
出典データセット
uspto-grants-2014_01
特許番号
US08637532B2

関連ノート

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