Ammonia → 4-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid amide

HRID 474482ノート

反応式

HRID 474482 の反応式
C[O:2][C:3]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[N:13]=[CH:12][N:11]=[C:10]2[NH:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([N:23]([C:25](=[O:34])[C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=2)[CH3:24])[CH:18]=1)=O.[NH3:35]>CO>[CH3:33][O:32][C:29]1[CH:28]=[CH:27][C:26]([C:25]([N:23]([CH3:24])[C:19]2[CH:18]=[C:17]([CH:22]=[CH:21][CH:20]=2)[CH2:16][NH:15][C:10]2[C:9]3[C:14](=[C:5]([C:3]([NH2:35])=[O:2])[CH:6]=[CH:7][CH:8]=3)[N:13]=[CH:12][N:11]=2)=[O:34])=[CH:31][CH:30]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 667635364-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid methyl ester

生成物 1

HCID 667640754-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid amide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-{3-[(4-Methoxy-benzoyl)-methyl-amino]-benzylamino}-quinazoline-8-carboxylic acid methyl ester from step d was dissolved in 1 ml 7N NH3 in methanol in a sealed vessel and stirred for 24 h at room temperature. The reaction mixture was evaporated and purified using preparative HPLC. The product was treated with HCl in methanol and concentrated in the SpeedVac.

後処理

  1. customThe reaction mixture was evaporated
  2. custompurified
  3. additionThe product was treated with HCl in methanol
  4. concentrationconcentrated in the SpeedVac

出典と根拠

ORDレコード
ord-bb3343391bb440f8b0e52f66bf36bca3
出典データセット
uspto-grants-2014_01
特許番号
US08637532B2

反応ノート

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