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3-Chloro-4-methoxyaniline → 1-(3-Chloro-4-methoxy-phenyl)-3-(5,8-difluoro-2-methyl-quinolin-4-yl)-urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloro-4-methoxyaniline | HCID 21441 | — |
| 反応物 | 2,2,2-Tribromo-N-(5,8-difluoro-2-methyl-quinolin-4-yl)-acetamide | HCID 22745136 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 1-(3-Chloro-4-methoxy-phenyl)-3-(5,8-difluoro-2-methyl-quinolin-4-yl)-urea | HCID 22745129 | 5.3% |
反応手順
Title compound (0.005 g) was prepared according to the method of Example 66 from acetamide D23 (0.118 g) and 3-chloro-4-methoxyaniline (0.039 g) but using pyridine as solvent. m/z (API+): 378 (MH+). 1H NMR δ: 2.62 (3H, s), 3.83 (1H, s), 7.13 (1H, d, J=9.0 Hz ), 7.28-7.40 (2H, m), 7.50-7.60 (1H, m), 7.74 (1H, d, J=2.6 Hz), 8.29 (1H, s), 8.86 (1H, d), 9.93 (1H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06699879B1 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-0f30a835c94a49a1a7eb4d5f1ff01618 |
| 出典メモ | uspto-grants-2004_03 |