3-Chloro-4-methoxyaniline → 1-(3-Chloro-4-methoxy-phenyl)-3-(5,8-difluoro-2-methyl-quinolin-4-yl)-urea

HRID 47449

反応式

HRID 47449 の反応式
BrC(Br)(Br)[C:3]([NH:5][C:6]1[C:15]2[C:10](=[C:11]([F:17])[CH:12]=[CH:13][C:14]=2[F:16])[N:9]=[C:8]([CH3:18])[CH:7]=1)=[O:4].[Cl:21][C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[NH2:25]>N1C=CC=CC=1>[Cl:21][C:22]1[CH:23]=[C:24]([NH:25][C:3]([NH:5][C:6]2[C:15]3[C:10](=[C:11]([F:17])[CH:12]=[CH:13][C:14]=3[F:16])[N:9]=[C:8]([CH3:18])[CH:7]=2)=[O:4])[CH:26]=[CH:27][C:28]=1[O:29][CH3:30]

参加物

4

反応物 2

HCID 214413-Chloro-4-methoxyanilineHCID 227451362,2,2-Tribromo-N-(5,8-difluoro-2-methyl-quinolin-4-yl)-acetamide

生成物 1

HCID 227451291-(3-Chloro-4-methoxy-phenyl)-3-(5,8-difluoro-2-methyl-quinolin-4-yl)-urea収率 5.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Title compound (0.005 g) was prepared according to the method of Example 66 from acetamide D23 (0.118 g) and 3-chloro-4-methoxyaniline (0.039 g) but using pyridine as solvent. m/z (API+): 378 (MH+). 1H NMR δ: 2.62 (3H, s), 3.83 (1H, s), 7.13 (1H, d, J=9.0 Hz ), 7.28-7.40 (2H, m), 7.50-7.60 (1H, m), 7.74 (1H, d, J=2.6 Hz), 8.29 (1H, s), 8.86 (1H, d), 9.93 (1H, s).

出典と根拠

ORDレコード
ord-0f30a835c94a49a1a7eb4d5f1ff01618
出典データセット
uspto-grants-2004_03
特許番号
US06699879B1

関連ノート

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