Acetic Anhydride → 2-methyl-4H-pyrido[2,3-d][1,3]oxazin-4-one

反応式

[NH2:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:11](OC(=O)C)(=O)[CH3:12]>>[CH3:11][C:12]1[O:5][C:4](=[O:6])[C:3]2[CH:7]=[CH:8][CH:9]=[N:10][C:2]=2[N:1]=1

参加物

反応物 2

HCID 7918Acetic Anhydride

HCID 729302-Aminonicotinic acid

生成物 1

HCID 108774362-methyl-4H-pyrido[2,3-d][1,3]oxazin-4-one

実験手順

2-Aminonicotinic acid (5 g, 36 mmole) was suspended in acetic anhydride (25 mL) then heated at reflux for 2 hours. The reaction mixture was concentrated under vacuum. The resulting residue was slurried with ethyl acetate and hexane then filtered to provide 5 g of 2-methyl-4H-pyrido[2,3-d][1,3]oxazin-4-one.

後処理

temperaturethen heated
temperatureat reflux for 2 hours
concentrationThe reaction mixture was concentrated under vacuum
filtrationthen filtered

出典と根拠

ORDレコード: ord-00ea0f44c1e74f03b42f5c2a112f37a3
出典データセット: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06699878B2

反応ノート

読み込み中…

参加物