Dimethylformamide → HCID 178515417、化合物

HRID 47452

反応式

HRID 47452 の反応式
[CH3:1][C:2]1[N:6]([C:7]2[N:17]=[CH:16][CH:15]=[CH:14][C:8]=2[C:9](OCC)=[O:10])[N:5]=[N:4][N:3]=1.CN(C)C=O.[O-]CC.[K+]>C(O)(=O)C>[N:5]1[N:6]2[C:7]3[C:8]([C:9]([OH:10])=[CH:1][C:2]2=[N:3][N:4]=1)=[CH:14][CH:15]=[CH:16][N:17]=3

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 12132861ethyl 2-(5-methyl-1H-tetrazol-1-yl)nicotinateHCID 23670592Potassium ethoxide

生成物 1

HCID 178515417HCID 178515417、化合物収率 89.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Ethyl 2-(5-methyl-1H-tetrazol-1-yl)nicotinate (6.3 g, 27 mmole) was covered with N,N-dimethylformamide (50 mL), potassium ethoxide (4.5 g, 54 mmole) was added and the reaction mixture was stirred at ambient temperature for 2 hours. The reaction mixture was poured into ice water containing about 17 mL of acetic acid. The resulting precipitate was isolated by filtration, washed with water then dried to provide 4.5 g of tetrazolo[1,5-a][1,8]naphthyridin-5-ol as an off white solid, m.p. 236° (decomposition). Analysis: Calculated for C8H5N5O: %C, 51.34; %H, 2.69; %N, 37.42. Found: %C, 51.23; %H, 2.77; %N, 37.25.

後処理

  1. additionwas added
  2. customThe resulting precipitate was isolated by filtration
  3. washwashed with water
  4. customthen dried

出典と根拠

ORDレコード
ord-6647a8eb3f0d4a87ae76f529a9f8da48
出典データセット
uspto-grants-2004_03
特許番号
US06699878B2

関連ノート

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