Methyl 2-formyl-3-(1-methyl-1H-pyrazol-4-yl)propanoate → HCID 178480213、化合物
反応式
[N+:1]([NH:4][C:5]([NH2:7])=[NH:6])([O-:3])=[O:2].[CH:8]([CH:10]([CH2:15][C:16]1[CH:17]=[N:18][N:19]([CH3:21])[CH:20]=1)[C:11](OC)=O)=[O:9]>C(O)C>[CH3:21][N:19]1[CH:20]=[C:16]([CH2:15][C:10]2[C:8](=[O:9])[N:6]=[C:5]([NH:4][N+:1]([O-:3])=[O:2])[NH:7][CH:11]=2)[CH:17]=[N:18]1参加物
4
反応条件
- 温度
- 70 °C
実験手順
To the solution of N-nitroguanidine (912 mg, 8.76 mmol) in ethanol (50.0 mL) was added methyl 2-formyl-3-(1-methyl-1H-pyrazol-4-yl)propanoate (858 mg, 4.38 mmol). It was stirred at 70° C. overnight. After removing the solvent, 10 mL water was added. Then HCl(conc) was added to adjust pH ˜3, and the solution was stirred at 0° C. for 1 h. The solid was collected after filtration. It was dried overnight at 50° C. to get the title compound as an off-white solid (674 mg, 61.5% yield). LCMS: rt=1.17 min, [M+H+]=251.1